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Gastroenterology. 2016 Dec 14. pii: S0016-5085(16)35488-9. doi: 10.1053/j.gastro.2016.12.005. [Epub ahead of print]
Low Risk of High-grade Dysplasia or Esophageal Adenocarcinoma Among Patients with Barrett’s Esophagus Less Than 1 cm (Irregular Z Line) Within 5 Years of Index Endoscopy.
Thota PN1, Vennalaganti P2, Vennelaganti S3, Young P4, Gaddam S5, Gupta N6, Lieberman D7, Sampliner R8, Falk GW9, Mathur S3, Kennedy K3, Cash BD10, Moawad F4, Bansal A3, Spaander MC11, Bruno MJ11, Vargo J12, Sharma P13.
Abstract
BACKGROUND & AIMS:
Many patients with a less than 1 cm segment of columnar metaplasia in 3 the distal esophagus, also called an irregular Z line, are encountered. These patients, often referred to as patients with Barrett’s esophagus (BE), are enrolled in surveillance programs. However, little is known about their risk of high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). We aimed to determine the incidence of HGD and EAC in patients with irregular Z line with intestinal metaplasia.
METHODS:
We performed a prospective, multicenter cohort study of patients who underwent endoscopic examination for BE at tertiary care referral centers in the United States and Europe. We analyzed data from 1791 patients (mean age, 56 ± 17 years) found to have non-dysplastic BE at the index endoscopy and after 1 year or more of follow up. Patients were followed for a median 5.9 years (interquartile range, 3.1-8.3 years). We calculated rates of progression to HGD or EAC between groups of patients with irregular Z line (n=167) and those with BE of 1 cm or more (n=1624).
RESULTS:
A higher proportion of patients in the irregular Z-line group were female (26.3%) than in the BE group (14.8% female BE) (P<.001). A lower proportion of patients in the irregular Z-line group were smokers (33.5%) than in the BE group (52.6% smokers). None of the patients with irregular Z line developed HGD or EAC during a median follow-up period of 4.8 years (interquartile range, 3.2-8.3 years). All 71 incident cases of HGD or EAC developed in patients with BE of 1 cm or more in length. On multivariate analysis, patients with irregular Z line and patients with BE with of 1 cm or more did not differ significantly in age, race, or duration of follow up.
CONCLUSIONS:
In a prospective, multicenter cohort study, we found that patients with irregular Z line do not develop HGD or esophageal cancer within 5 years after index endoscopy.
Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.
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